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Correlation of hematological markers in psoriasis with the severity of the disease

2026-08-19T10:32:05Z

Title: Correlation of hematological markers in psoriasis with the severity of the disease Authors: Vishnavi pran kanath Abstract: Background: Psoriasis is atchronic and recurrent disease that affects the skin, joints, and nails, characterised as an immune-mediated disorder with systemic involvement.tThis can lead to changes in the haemotological parameters as well. The tpsoriasis area and severity index (PASI) is a tool that assesses the severity of psoriasis lesions and the therapeutic response of the patients.tVarious studies have shown correlation between the PASI and haematological parameters. Aim: To assess the haematological parameters- platelet-lymphocyte ratio (PLR), platelet distribution width (PDW), neutrophil-lymphocyte ratio (NLR), red cell distribution width (RDW), mean platelet volume (MPV) and plataelet count (PLT) in psoriasis patients. These values will also be correlated with the disease severity. Materials and methods: A cross-sectional case-control study was conducted from May 2023 to January 2025 on 260 psoriasis patients and controls. The study was done at thetDepartment of Dermatology, Shri BM Patil Medical College Hospital and Research Center, Vijayapura.tComplete hemogram was done for all the study participants and the parameters were correlated with PASI in the cases. Additionally, the parameters were compared with that of controls. Results: PLT and NLR (p =0.045 and p =0.002 respectively) had a“statistically significant positive correlation”with PASI. On comparison of cases to controls, a statistically significant elevation was seen in the MPV (p =0.012 ) and NLR (p =0.012) in cases. Conclusion: NLR, PLT and MPV can be used as cost-effective and affordable laboratory markers in the assessment of disease severity in psoriasis, in conjunction with PASI (NLR, PLT).

Association between acne vulgaris and body mass index in adult population: a tertiary hospital-based prospective study in north karnataka, india

2026-08-19T10:27:17Z

Title: Association between acne vulgaris and body mass index in adult population: a tertiary hospital-based prospective study in north karnataka, india Authors: Tvisha prasad Abstract: Introduction: Acne vulgaris affects pilosebaceous units, manifesting as comedones, papules, pustules, and nodules. While primarily affecting adolescents, it’s prevalence may continue into adulthood. Beyond cosmetic concerns, acne significantly affects psychological wellbeing and quality of life. Its pathophysiology involves four key factors: increased sebum production, abnormal follicular keratinization, Cutibacterium acnes colonization, and inflammation. Androgens play a crucial role, but modern research recognizes additional influences including diet, genetics, environment, and metabolism, establishing acne as a complex, multifactorial condition. A possible relationship between adult acne severity and body mass index has been explored in recent studies. Aims and objectives: We sought to assess the impact of body mass index on severity of acne. Materials and methods: In this single centre prospective case-control study 312 acne cases and 312 age-matched controls were included, and their body mass index were also calculated according to WHO and Asian classification. Patients and controls above 18 years of age who were age and gender-matched, presenting to the Department of Dermatology, Shri BM Patil Medical College Hospital and Research Center, Vijayapura were included in the study. Results: The mean age of cases was 23.08 years, while that of controls was 25.03 years. A majority of the cases (60.3%) belonged to the younger age group (≤22 years). Additionally, there was a female predominance, with a female-to-male ratio of 1.35:1. There was no statistically significant difference between BMI of males and females. On comparing the mean BMI, it was ix Docusign Envelope ID: 5748B4DB-4877-4559-9591-11F3681467C1 lower in cases (21.659) than in controls (22.294) (p = 0.032), indicating that acne cases tend to have slightly lower BMI. Limitations: Dietary and lifestyle factors were not recorded. Conclusions: This study provides novel evidence of an inverse relationship between BMI and both acne prevalence and severity in an adult population from North Karnataka, India.

Clinical and dermoscopic features of facial and non-facial lesions in patients with papulosquamous disorders - a cross sectional study

2026-08-19T10:23:32Z

Title: Clinical and dermoscopic features of facial and non-facial lesions in patients with papulosquamous disorders - a cross sectional study Authors: Devavrat sanjay gore Abstract: Background- Papulosquamous disorders are common, heterogenous group of disorders. Dermoscopic features of various papulosquamous disorders are well-characterized. Face is not commonly involved in these conditions, when involved they present differently because facial topography is different from non-facial skin. Clinical and dermoscopic features may vary for same reason. Further, face being a cosmetically significant area, invasive biopsy for confirmation of the diagnosis cannot be performed routinely. Aims and objectives- • To study the clinical and dermoscopic features of facial and non-facial lesion in patients with papulosquamous disorders namely, plaque psoriasis, classical lichen planus, pityriasis rosea, seborrheic dermatitis and pityriasis rubra pilaris. • To correlate clinical and dermoscopic features of different papulosquamous disorders. Materials and methods- It is an hospital based cross-sectional study of 55 patients presenting with various papulosquamous disorders. Patients were subjected to detailed clinical and dermoscopic examination and categorized into plaque psoriasis, classical lichen planus, pityriasis rosea, seborrheic dermatitis and pityriasis rubra pilaris. Results- Psoriasis was most common diagnosis (65.45%), followed by lichen planus (23.64%), while pityriasis rosea (3.64%), pityriasis rubra pilaris (3.64%), and seborrheic dermatitis (3.64%) were less frequent. The mean age for psoriasis and lichen planus was 28.01 and 27.23 years, respectively. Males were more frequently affected (65.45%). 9 Docusign Envelope ID: 22E0AD42-75BC-4A18-8141-1D1A1E222BD3 Dermoscopy of psoriasis revealed site-specific variations, with a red background (52.78%) and diffuse vessel distribution (97.14%) being predominant in non-facial lesions, while facial lesions showed a pink background (50%) and patchy vessel distribution (42.31%) (p < 0.001). White scales were consistently present in both locations. In lichen planus, a violaceous pink background was most common in both facial (38.46%) and non-facial (61.54%) lesions, and Wickham striae were observed in 84.61% of cases. No significant site-specific variations were noted. Pityriasis rosea lesions showed a uniform pink background with white collarette scales and brown globules, with perifollicular scaling and hypopigmentation noted in 50% of cases. Pityriasis rubra pilaris exhibited a pinkish red background in both facial and non-facial lesions, with perifollicular scaling (100%) and diffuse white scaling (100%). Dermoscopic features were largely consistent across sites. Seborrheic dermatitis showed a pinkish background in both facial and non-facial lesions, whitish scales (100%) being the predominant features. Conclusion- Dermoscopic analysis revealed significant site-specific differences in psoriasis, while lichen planus, PRP, PR, and SD displayed more consistent features across facial and non facial lesions. Dermoscopy remains a valuable tool for diagnosing and differentiating papulosquamous disorders.

Dermatophyte infections in children: a prospective study in a tertiary care hospital

2026-08-19T10:19:01Z

Title: Dermatophyte infections in children: a prospective study in a tertiary care hospital Authors: Anaswarasree Abstract: BACKGROUND: The prevalence of dermatophytic infections has recently surged worldwide, particularly in tropical nations like India. This is associated with change in the clinical pattern and mycological profile with poor response to treatment. This clinico-epidemiologic study helps to clarify the determinants of the trends associated with these dermatophytosis and the health burden of illness in the pediatric population. AIMS AND OBJECTIVES: 1. To determine the epidemiological profile of dermatophytosis among children (less than 15 years of age) attending dermatology OPD at tertiary care hospital. 2. To assess clinico-mycological characteristics of dermatophytosis in pediatric population. MATERIALS AND METHODS: It is a hospital-based cross-sectional study. Children below 15 years of age clinically diagnosed to have dermatophytosis were be enrolled for the study. Detailed history about duration of disease, socioeconomic status, past history of medication and consultation, personal and family history were recorded. The Patients were examined to determine the clinical type of dermatophytosis. Specimen (skin scraping, hair, or nail clippings) for microbiological investigations was collected from the lesion. It was utilized for preparing a 10% KOH mount for direct microscopy for visualization of fungal hyphae. Irrespective of KOH mount result, the specimen was also inoculated in 3 media, Sabouraud dextrose agar without chloramphenicol and cycloheximide (SDA), Sabouraud dextrose agar with Chloramphenicol, and cycloheximide Docusign Envelope ID: 224F113D-B089-4DB4-B39B-674406D6C125 (SDA with antibiotics) and Dermatophyte test media (DTM). It was further sent to the microbiology laboratory for the purpose of incubation and isolation of species. RESULTS The most commonly affected age group in this study was 13-15 years with male predominance. Maximum patients (39.9%) presented with 1-2 months duration of the lesion with 27.5% of the patients having history of self-medication. Past history of similar complaints was observed in 21.6 % of the patients and 41.8 % of the patients had similar complaints among family members or close contacts. Tinea Corporis was the most common clinical diagnosis followed by tinea Capitis. Tinea Corporis with tinea Capitis was the commonest presentation among the mixed type of dermatophytosis. Direct microscopy of a 10% KOH mount demonstrated fungal hyphae in 81 % of patient’s samples and culture positivity for dermatophytes seen was in 51 %. Trichophyton mentagrophyte (32.7 %) was the most common specie isolated followed by Trichophyton rubrum (12.4%). CONCLUSION: • Topical corticosteroids in combination with antifungal agents available over counter are grossly abused leading to chronic treatment resistant dermatophytosis. • Clinical failure from antifungal medication due to the persistence of risk factors, poor personal hygiene and inadequate knowledge of the infection and its features of treatment in the general population contribute to treatment resistant dermatophytosis. • This clinic-epidemiologic study helps to determine the epidemiological trends, the nature of the disease, the predisposing factors and the causative species of dermatophytosis in the pediatric population.