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Evaluation Of Antiepileptic Activities Of Ramipril And Telmisartan And Potentiation Of The Antiepileptic Effect Of Phenytoin Sodium And Valproic Acid In Rat Models

Fri, 01 Jan 2021 00:00:00 GMT

Title: Evaluation Of Antiepileptic Activities Of Ramipril And Telmisartan And Potentiation Of The Antiepileptic Effect Of Phenytoin Sodium And Valproic Acid In Rat Models Authors: Sneha, Guidance :Dr. Akram A. Naikawdi Abstract: Background: Epilepsy is a chronic disorder with heterogeneous symptoms characterized by recurrent seizures resulting from abnormal discharge of cerebral neurons. Several different drugs are available and act through diverse mechanisms. However, most of them have a low safety margin and provide seizure control in 60 - 70% of patients. Attempts are being made to explore the anti-epileptic potentials of several different groups of drugs. Drugs interfering with Renin- Angiotensin- Aldosterone system (RAAS) have shown potential as an add-on therapy with existing anti-epileptic drugs. Objectives: To evaluate the anti-epileptic potential of Ramipril and Telmisartan using the Maximum Electroshock (MES) model and PTZ model in rats and also to evaluate its effect as an add-on with Phenytoin and Sodium Valproate Methods: The study was conducted on Male Wistar rats to investigate the effects of Ramipril (2mg/kg) and Telmisartan (30 mg/kg) individually, as well as in combination with Phenytoin and Sodium Valproate, in models of epilepsy. In the maximal electroshock (MES) model, the rats were administered Ramipril (2mg/kg) and Telmisartan (30 mg/kg) alone and in combination with Phenytoin (Ramipril 1mg/kg + Phenytoin Sodium 50 mg/kg) and (Telmisartan 15 mg/kg + Phenytoin Sodium 50 mg/kg). Phenytoin Sodium (100mg/kg) was used as the standard reference. The effects were assessed based on the abolition of Hind Limb Tonic Extension (HLTE), serving as an index of anti-epileptic activity. Similarly, in the pentylenetetrazole (PTZ) model, the rats received Ramipril (2mg/kg) and Telmisartan (30 mg/kg) alone and in combination with Sodium Valproate (Ramipril 1mg/kg + Sodium Valproate 125 mg/kg) and (Telmisartan 15 mg/kg + Sodium Valproate 125 mg/kg). Sodium Valproate (250mg/kg) was the standard reference. The effects were evaluated based on the delay in the onset of convulsions, another index of anti-epileptic activity. Results: Both Ramipril and Telmisartan exhibited significant anti-epileptic effects when used alone. Both drugs potentiated the anti-epileptic effect of Phenytoin and Sodium Valproate. Conclusion: Drugs interfering with RAS, like Ramipril (ACEI) and Telmisartan (ARB), can be used alone for generalized tonic-clonic convulsions (GTC). In patients receiving ACEIs or ARBs for other clinical conditions, a dose of Phenytoin and Sodium Valproate can be reduced if these patients also have epilepsy.

To Evaluate And Compare The Antiepileptic Effect Of Calcium Channel Blockers And Their Ability To Potentiate The Antiepileptic Effect Of Existing Antiepileptic Drugs In Rat Models

Sun, 01 Jan 2017 00:00:00 GMT

Title: To Evaluate And Compare The Antiepileptic Effect Of Calcium Channel Blockers And Their Ability To Potentiate The Antiepileptic Effect Of Existing Antiepileptic Drugs In Rat Models Authors: Vijayalaxmi M., Uppin Abstract: Background: The currently available antiepileptic drugs have a low therapeutic index, and provide satisfactory seizure control in only 60-70% of patients. Calcium channel blocker has shown potentials of a useful add-on drug for the existing antiepileptic drugs. Materials and Methods: Antiepileptic potential of calcium channel blockers (nifedipine and verapamil) was evaluated in MES and PTZ models of epilepsy in comparison and combination with phenytoin (25 mg/kg) and sodium valproate (250 mg/kg) in albino wistar rats; half the dose was used when calcium channel blockers (nifedipine and verapamil) was combined with either phenytoin or sodium valproate. The time taken before the onset of clonic convulsions (latency), the duration of clonic convulsions, the percentage of seizure protection and percentage mortality were recorded. Results: Calcium channel blockers (nifedipine and verapamil) were found to reduce the durations of tonic extensor phase, duration of convulsion in a statistically significant way in the both MES and PTZ model; and while used in combination with phenytoin and/or sodium valproate, the results were statistically significant than both the drugs given individually. In both these group statistically significant increased percentage epilepsy protection and decrease in percentage mortality was noted when compared to control groups (p < 0.05). Conclusion: Calcium channel blockers (nifedipine and verapamil) have shown potency as an individual antiepileptic drug as well as a useful add-on therapy with standard antiepileptic drugs like phenytoin and sodium valproate in both the models of epilepsy.

“Critical Analysis Of Fixed Dose Combinations (Fdcs) Prescribed In A Tertiary Care Hospital In Vijayapura”

Mon, 01 Jan 2018 00:00:00 GMT

Title: “Critical Analysis Of Fixed Dose Combinations (Fdcs) Prescribed In A Tertiary Care Hospital In Vijayapura” Authors: Kamni, Supreet

“ Evaluation Of Effect Of Metformin On Clozapine Induced Metabolic Derangement In Rats”

Mon, 01 Jan 2018 00:00:00 GMT

Title: “ Evaluation Of Effect Of Metformin On Clozapine Induced Metabolic Derangement In Rats” Authors: Syed Shoib, Md Hussaini