Neuroanatomical changes in Parkinson's disease in relation to cognition: An update.

Abstract

Parkinson's disease (PD) is characterized by slowness of movement, rigidity, tremor, postural instability, and often cognitive impairments.[1] Although motor features are more prominent in PD, nonmotor features also have been diagnosed in PD patients.[2] Acetylcholine, norepinephrine, and serotonin may have a role in nonmotor features of PD. Features include cognitive impairment, psychological, autonomic, and sleep disorders which decrease the quality of life further.[3,4] The pathophysiological changes underlying impairment of cognition in PD are complex and not fully understood till date.[5] Hence, understanding