A comparative study of carbetocin 100 mcg iv and oxytocin 10 iu iv in the prevention of postpartum hemorrhage following emergency cesarean delivery

Abstract

BACKGROUND: Obstetrical bleeding is bleeding in pregnancy that occurs before, during, or after childbirth.Between 2003 and 2009, bleeding accounted for 27% of maternal deaths globally. AIMS AND OBJECTIVES : Comparison of carbetocin 100mcg iv and oxytocin 10iu iv in the prevention of postpartum hemorrhage following emergency caesarean section. MATERIAL AND METHODS: A prospective interventional study with patients admitted for delivery in the Department of Obstetrics and Gynaecology in B.L.D.E. Shri B.M. Patil's Medical College, Hospital and Research Centre, Vijayapura from march 2023 to march 2025 with the singleton pregnancy with the period of gestation of 34 weeks and above undergoing emergency caesarean delivery were recruited. RESULTS: Carbetocin group (8.6%) compared to the Oxytocin group (18.9%) (p = 0.02),and a greater proportion of patients in the Carbetocin group (162 out of 175, 92.5%) had blood loss between 750-1000 ml, compared to 142 out of 175 (81.1%) in the Oxytocin group. This reduction in blood loss translated into a lower need for blood transfusions (1.1% vs. 4.6%, p = 0.03) and additional uterotonic agents (2.9% vs. 8.6%, p = 0.04) in the Carbetocin group. CONCLUSION : The findings of this study demonstrate that Carbetocin 100 mcg IV is significantly More effective than Oxytocin 10 IU IV in preventing postpartum hemorrhage (PPH) Following emergency caesarean section