Abstract:
To investigate the effect of low dose amlodipine v/s nifedipine on serum cholesterol profile of
rabbits receiving standard diet. Methods: Fourty Newzealand rabbits were selected for the study. Their
cholesterol profile was estimated at the beginning of the study. Rabbits were grouped into 4 groups
receiving standard diet (control group), standard diet + vehicle propylene glycol, standard diet + nifedipine
dissolved in propylene glycol and standard diet + amlodipine dissolved in propylene glycol. Along with
standard diet they were treated with respective drugs for ten weeks. At the end of ten weeks serum
cholesterol profile was estimated. Results: The cholesterol profile was estimated at the beginning and at the
end of ten weeks. Total cholesterol in the amlodipine group decreased from 97±4.06 mg/dl to 90±4.2 mg/dl
and HDL-Cholesterol increased from 32.01±4.40 mg/dl to 37±4.60 mg/dl after 10 week treatment but these
changes were not significant. LDL cholesterol decreased significantly in rabbits with low dose of
amlodipine from 55.42±3.32 mg/dl to 32.40±3.22 mg/dl and. In the nifedipine group there was a slight
increase in total cholesterol from 102.49±5.16 mg/dl to 106±5.39 mg/dl, HDL cholesterol from 34.10±2.80
to 35.16±2.82 mg/dl and LDL cholesterol also increased from 56.20±2.20 mg/dl to 59.00±2.20 mg/dl after
10 week treatment. Conclusion: The study shows amlodipine produces favorable alterations in serum
cholesterol profile.
