Abstract:
The diabetes induced dyslipidemia may lead to an alteration in RBC membrane
cholesterol/phospholipids ratio in diabetic subjects resulting in an alteration in RBC membrane
properties. It has been observed in our laboratory that diabetes induced dyslipidemia causes a
change in RBC membrane lipid composition in type 2 diabetic subjects. The effect of various oral
anti diabetic drugs and or Insulin therapy on diabetes induced RBC membrane lipid alteration is
not established. Hence the present work was undertaken to study the influence of anti diabetic
drugs and or Insulin on RBC membrane lipid composition in type 2 diabetic subjects. Blood
samples from randomly selected type 2 diabetic subjects were collected after obtaining written
consent. The plasma lipids as well as RBC membrane lipids were estimated. The study group
include normal subjects (group-1), control diabetics diabetic subjects (group-2), diabetic
subjects receiving oral drugs (group-3), diabetic subjects receiving insulin (group-4) and diabetic
subjects receiving both oral drugs and insulin (group-5).
