Abstract:
Interpenetrated polymer network (IPN) microparticles of sterculia gum and sodium alginate loaded
with repaglinide were developed by ionic gelation and emulsion crosslinking method. The drug
entrapment efficiency was as high as 91%. FTIR and TG analyses confirmed the crosslinking and
IPN formation. Microparticles have demonstrated the drug release up to 24h depending upon type
of crosslinking agents; the glutaraldehyde treatment of ionically crosslinked microparticles has
resulted in decreased drug release rate. The invivo
antidiabetic
activity performed on
streptozotocin induced diabetic rats indicated that the pristine repaglinide has shown maximum
percentage reduction of elevated blood glucose within 3h and then the percentage reduction in
blood glucose was decreased. In the case of rats treated with KA8 IPN microparticles, percentage
reduction of elevated glucose was slow as compared to pristine drug within 3h, but it was
gradually increased to 81.27% up to 24h.
