Abstract:
In the present study, an attempt was made to prepare and evaluate the natural polymers based compression coated
tablets for controlled release of an antibiotic, cefadroxil monohydrate. The core tablets were prepared by direct
compression method and compression coating granules were prepared by wet granulation method using sodium
alginate and xanthan gum. The weight and drug content of all the tablets were found to be uniform. The hardness
and friability were found within specified range. The core tablets released 99% drug within 1 h, while the
compression coated tablets were capable of releasing the drug for 24 h. The coating formula containing more
amount of aluminum chloride released the drug slowly as compared to barium chloride. Drug release mechanism
was found to be non-Fickian transport type.
