Formulation and evaluation of compression coated tablets for controlled release of cefadroxil monohydrate.

Abstract

In the present study, an attempt was made to prepare and evaluate the natural polymers based compression coated tablets for controlled release of an antibiotic, cefadroxil monohydrate. The core tablets were prepared by direct compression method and compression coating granules were prepared by wet granulation method using sodium alginate and xanthan gum. The weight and drug content of all the tablets were found to be uniform. The hardness and friability were found within specified range. The core tablets released 99% drug within 1 h, while the compression coated tablets were capable of releasing the drug for 24 h. The coating formula containing more amount of aluminum chloride released the drug slowly as compared to barium chloride. Drug release mechanism was found to be non-Fickian transport type.