Abstract:
In the present investigation, hydrogel based interpenetrating network (IPN) discs
of poly(vinyl alcohol) and poly(vinyl pyrrolidone) loaded with an anti-diabetic drug,
glipizide were prepared by chemical crosslinking method. The prepared discs were
characterized by thermogravimetric analysis (TGA), differential scanning calorimetric
analysis (DSC) and X-ray diffractometry (XRD). The swelling behavior and drug release
were dependent upon the crosslink density. The IPN hydrogel discs were capable of
releasing drug up to 24 h. The discs which were prepared with higher concentration of
glutaraldehyde released the drug more slowly. The release data were fitted to an empirical
equation to determine the transport mechanism, which indicated the non-Fickian trend for drug transport.
