Study on relationship between thyroid hormones and glucose homeostasis among post menopausal diabetic women

Abstract

Aim and Objectives: We aimed to establish the link between thyroid hormones and glucose homeostasis in pre and post menopausal non-diabetic women as well as in pre and post menopausal diabetic women and to compare the relation between thyroid hormones and glucose homeostasis with pre and post menopausal non-diabetic and diabetic women. Materials and Methods: It was a cross sectional study. Total 200 women, among them 50 premenopausal non-diabetics and 50 premenopausal diabetics aged between 25-45 years, 50 post menopausal non-diabetics and 50 post menopausal diabetics aged between 46-65 years were selected for the present study. Anthropometric and Physiological parameters were recorded. Haematological parameters which includes Complete blood picture count, Blood glucose profile includes Fasting Blood sugar and Glycosylated haemoglobin and thyroid profile which includes TSH, T3, T4 and Reproductive profile includes Luteinizing hormone, Follicle stimulating hormone, Estrogen and Progesterone hormonal analysis were done by using standard procedures. Statistical analysis was done using One Way Anova followed by ‗Post Hoc t tests‘ were done using SPSS software version 16. Results: We found there is an increase in FBS of pre menopausal diabetics but HbA1c is same in both pre and post menopausal diabetics. There is an increase in T3 and T4 levels and decrease in TSH levels in post menopausal diabetics. LH, FSH and E2 and P4 showed to be decreased in post menopausal diabetics. Conclusion: These findings suggest that current thyroid disorders deteriorate the glucose metabolism in post menopausal women suffering from diabetes mellitus. So monitoring of thyroid profile in post menopausal diabetic women would be a better therapy in future.