Abstract:
Objective: To assess the link between vitamin D and cardiovascular diseases (CVD) in the
percpective of angiogenic factors among the various types of CVD patients admitted in
ICCU.
Methods: Cross sectional study was conducted on CVD patients age ranging from 40 to 80
years who were diagnosed for first time and admitted in ICCU of BLDE(DU) Shri.B.M.Patil
Medical College , Hospital and Research Centre Vijayapur ,Karnataka(India).
The following parameters were tested: Anthropometric parameters: height (cms), weight (kgs), BMI (kg/m 2) and BSA (m 2); Physiological parameters: pulse rate in
(beats/min), systolic blood pressure (mmHg), diastolic blood pressure (mmHg), pulse
pressure (mmHg) and mean arterial pressure (mmHg); Hematological parameters: RBC,
WBC, HB%, PCV, Platelet count and blood indices like MCV, MCH, MCHC;
echocardiography; electrocardiography; biochemical parameters: triglyceride, cholesterol,
HDL, LDL, VLDL, serum creatinine, CPK-MB, serum sodium, potassium, calcium and
vitamin D; Oxidative and nitrosative stress measure: serum malondialdehyde (MDA),
nitric oxide (NOx) concentration; antioxidant capacity: serum superoxide dismutase (SOD)
activity, and vascular endothelial growth factor (VEGF) and nitric oxide synthase (NOS3).
Results: The increase in white blood cells (WBCs) level in present study indicate the
inflammatory process in the physiological system. Further increase in the ESR is indicative of
myocardial damage with leakage of proteins. As dyslipidemia is associated with various types
of stress factors and MI, HHD and IHD are definitely generate more stress among all the
types of CVD.Our results show significantly lower levels of vitamin D in all groups of CVD
patients. Results also found higher levels of MDA , significantly lower levels SOD and lower
levels NO. We found decreased VEGF levels in present study in groups
3(IHD),4(Angina),6(RHD) and 7(Cardiomyopathy) and decreased levels of NOS3 in all
groups of CVD patients
Conclusion: Results clearly shows that vitamin D is an important factor for the regulation of
cardiovascular health. Deficiency of vitamin D leads to most types of CVD in present study.
Possibly vitamin D influences angiogenic factor like VEGF and alter cardiovascular
remodeling. Further it may be concluded that the role of vitamin D induced cardiovascular
remodeling depends on nature and types of CVD.
