Abstract:
An ideal induction agent for general anaesthesia should have hemodynamic
stability, minimal respiratory side effects and rapid clearance. Sudden hypotension
has a deleterious effects on maintaining the circulation to vital organs. Presently
Etomidate and Propofol are popular rapid acting inducing agents.
MATERIALS AND METHODS:
Present randomized study was conducted on eighty patients after informed
consent, comprising of forty patients each. Both received Fentanyl 2 microgm/kg and
Glycopyrrolate 0.2 mg as premedication ten minutes before induction, followed by
Etomidate 0.3 mg/kg given slowly over 45 seconds in the first group and Propofol 2.5
mg/kg for induction of anaesthesia in the second group.
RESULTS:
In this study the heart rate changes are significant between the groups.
Maximum decrease in SBP, MAP and DBP is seen in group P compared to group E at
2-3 minutes of induction and 5minutes of post intubation. Group E is more
hemodynamically stable compared to group P.
Pain on injection was more in group P, 11 patients had grade I, 6 patients
grade II and 2 patients grade III pain on injection respectively, where as in group E 7
patients had grade I pain, 1 patient had grade II pain on injection.
Among forty patients in group E, 10 patients developed grade I myoclonus,
grade II and grade III in 5 and 1 patients respectively. Among forty patients in group
P, 3 patients developed grade I myoclonus.
The apnea occurred in 14 out of 40 patients in group E and 39 out of 40
patients in group P patients.
