Comparative Study Of Etomidate And Propofol For Induction Of General Anaesthesia

Abstract

An ideal induction agent for general anaesthesia should have hemodynamic stability, minimal respiratory side effects and rapid clearance. Sudden hypotension has a deleterious effects on maintaining the circulation to vital organs. Presently Etomidate and Propofol are popular rapid acting inducing agents.

MATERIALS AND METHODS: Present randomized study was conducted on eighty patients after informed consent, comprising of forty patients each. Both received Fentanyl 2 microgm/kg and Glycopyrrolate 0.2 mg as premedication ten minutes before induction, followed by Etomidate 0.3 mg/kg given slowly over 45 seconds in the first group and Propofol 2.5 mg/kg for induction of anaesthesia in the second group.

RESULTS: In this study the heart rate changes are significant between the groups. Maximum decrease in SBP, MAP and DBP is seen in group P compared to group E at 2-3 minutes of induction and 5minutes of post intubation. Group E is more hemodynamically stable compared to group P. Pain on injection was more in group P, 11 patients had grade I, 6 patients grade II and 2 patients grade III pain on injection respectively, where as in group E 7 patients had grade I pain, 1 patient had grade II pain on injection. Among forty patients in group E, 10 patients developed grade I myoclonus, grade II and grade III in 5 and 1 patients respectively. Among forty patients in group P, 3 patients developed grade I myoclonus. The apnea occurred in 14 out of 40 patients in group E and 39 out of 40 patients in group P patients.