Nephroprotective effect of black tea extract on cadmium induced male Wistar rats

Abstract

Introduction and Aim: Cadmium is an environmental pollutant and potential nephrotoxic to humans. Increase in industrialization is the major cause for heavy metal pollution and these heavy metals disrupts physiological homeostasis. Chelation therapy will be useful amelioration of heavy metal toxicity. This research was designed to understand the nephroprotective properties of black tea extract on cadmium induced renal toxicity in experimental rats. Materials and Methods: Adult rats were kept into four groups (n=6/group). In that group 1: control group (normal saline), group 2: cadmium chloride (CdCl2, 1.0 mg/kg, body weight; intraperitoneal), group 3: black tea extract and group 4: cadmium chloride plus black tea extract and processed for histopathology of kidney. Results: Supplementation of black tea extract improves kidney architecture of rats exposed with cadmium chloride group. Conclusion: Black tea extract seems to be nephroprotective against cadmium induced oxidative stress observed in experimental rats.