Abstract:
The latest pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is known to manifest in various
forms, ranging from a mild illness to a life-threatening condition. Though lung cavitation has not been commonly reported as a post
Coronavirus Disease-2019 (COVID-19) infection complication, there has been a rise in the number of patients presenting with lung
cavitation post the viral infection. In this case series, authors have reported four cases of lung cavitation developed post COVID19 infection. Three out of four patients were newly diagnosed cases of diabetes, all received steroids as a part of treatment for
COVID-19 infection. Three patients showed a temporary improvement in their condition after COVID-19 treatment, in the form of
decreasing trends of inflammatory markers and decreased total count, but subsequently developed signs of super added infection
during the course of their illness. Two patients had associated sino-orbital mucormycosis. Two patients required the support of
non invasive ventilation and did not show clinical improvement, while one amongst the two succumbed to the infection. The cause
for the development of lung cavities post COVID-19 infection is difficult to speculate it appears to be multifactorial with factors
including isolated bacterial, fungal infections or bacterial and fungal co-infection, SARS-CoV-2 specific inflammatory pathways,
and the immunosuppressive effects of glucocorticoids
