Abstract:
Abstract
Background: Detection of UTI causing pathogens and analysing resistance pattern of these
pathogens to commonly prescribed antibiotics in the clinical practice is essential and helpful in
improving the efficacy of empirical treatment.
Objectives: this study was conducted to analyse the current trend of antimicrobial drug
resistance pattern of bacteria isolated from patients of urinary tract infection.
Methods: A total of 120 positive urine culture and sensitivity reports of either sex and all the age
groups were analysed. Sensitivity/resistance of isolated microorganisms to commonly used
antimicrobial agents was detected by Kirby-Bauer disc diffusion method in the laboratory.
Results: E coli (50%) was the most common organism isolated followed by Klebsiella (20%),
Pseudomonas aeruginosa (10%), Enterobacter (7%), Staphycococcus aureus (5%), CONS (5%)
and Citrobacter (3%). The overall antimicrobial sensitivity pattern to uropathogens was the
highest to FOS (70%) and NFT (70%). Moderate susceptibility was seen with AMI (67%) and
C+S (51%).Highest resistance was seen with C+C (92.5%) followed by AMP (91%), and other
Penicillins, AZI, other Cephalosporins, Fluoroquinolones, COT.
Conclusion: This study provides valuable laboratory data to monitor the status of antimicrobial
resistance among uropathogens and to improve treatment recommendations in a specific
geographical region. From the study, it is clear that, E. coli is still the most common
uropathogen. Sensitivity to nitrofurantoin, fosfomycin and amikacin are still retained and may be
prescribed for complicated UTI, hence they should be used as a reserve antibiotics to prevent the
development of resistance.
