Abstract:
BACKGROUND AND OBJECTIVES:
Diabetic nephropathy (DN) is the most common cause of chronic kidney
disease worldwide.1-2In the wake of the current epidemic of diabetes mellitus (DM),
the prevalence of DN and end stage renal disease (ESRD) is projected to rise.3
Different therapeutic strategies targeting DN have been explored such as tight
glycemic control, 4
tight blood pressure control5
and various inhibitors of the renin
angiotensin aldosterone system (RAAS).6-8 while these therapies appear to slow the
progression of kidney disease due to diabetes, none of them are curative. Thus we
require adjunctive therapeutic strategies; especially in patients with complications of
treatment or lack of appropriate response.9
hence there is a pressing interest to identify
other potentially modifiable factors in the progression of DN.
Inflammation and endothelial dysfunction appear to play a central role in the
onset and the progression of DN. Recent evidence has emerged in the last decade to
suggest uric acid is an inflammatory factor and may play a role in endothelial
dysfunction.
Studies suggest that treatment of diabetic nephropathy may be benefited by
treatment with xanthine oxidase inhibitor.10
The aim of this study is to find an association between serum uric acid level
and albuminuria in type 2 diabetes mellitus (T2DM).
METHODS:
This study was carried out in B.L.D.E.U’s Shri B.M. Patil Medical College
Hospital and Research Centre, Vijayapur, Karnataka; during the period from
December 2013 to July 2015. A total of 56 patients who were known case of Type 2
X
diabetes mellitus were included in the study. The blood of the selected subjects were
analysed for Serum uric acid and Urine albumin creatinine ratio.
RESULTS:
Serum uric acid levels for, and
1. Normoalbuminuric patients=4.09±1.36 mg/dl
2. Microalbuminuric patients=5.21±1.60 mg/dl
3. Macroalbuminuric patients=7.38±0.87mg/dl
Serum uric acid level correlated positively with urinary albumin creatinine
ratio (r = 0.559, p = <0.001).
CONCLUSION:
Serum uric acid had a significant positive correlation with albuminuria in type
2 diabetes mellitus.
