Effect of bioactive molecules from phytochemical data base as possible therapeutic agents on aortic tissue proteins (ACE2 and MMP-7) in hypertensive rat model using in silico and in vivo methods

Abstract

In conclusion, β-sitosterol supplementation demonstrates promising therapeutic possibilities in modifying cardiovascular complications associated with L NAME-induced hypertension in rats. Its beneficial effects encompass regulating body weight, heart rate, blood pressure, autonomic functions, oxidative stress, and MMP-7 gene expression in cardiovascular remodelling. This study provides valuable insights into the various mechanisms underlying the cardioprotective effects of β-sitosterol. It highlights its significance as a potential adjunctive therapy for hypertension and associated cardiovascular disorders. Further research is needed to elucidate its precise mechanisms of action and therapeutic efficacy in clinical settings.